Honors:                       Salutatorian                                                              1979

National Honor Society

BoysState

Scarborough High School

Scarborough,Maine

Eagle Scout                                                              1977

Academic Honors:  A.B. Magna Cum Laude                                         1983

Summa Cum Laude in Biochemistry

BowdoinCollege

Graduated top tenth percentile                              1987

UVMCollegeof Medicine

Awards:                     Duke University Medical Center                           1995

Distinguished Faculty Fellow’s Award for Resident Teaching

AmericanCollegeof Obstetricians & Gynecologists    1995

Ethicon Innovations in Gynecologic Surgery Award

1997 Association of Professors of Gynecology & Obstetrics

Excellence in Teaching Award

1998 Council on Resident Education in Obstetrics &                                       Gynecology

National Faculty Award for Excellence in Resident Education

ACADEMIC APPOINTMENTS:

Duke University Medical Center                                       1993-1995

Department of Obstetrics and Gynecology

Division of Gynecologic Subspecialties

Associate

Fellow in Urogynecology and  Reconstructive  Pelvic Surgery

 

University of North Carolina, Chapel Hill                     1996- present

Department of Obstetrics and Gynecology

SchoolofMedicine

Clinical Professor

SOCIETIES: AmericanCollege of Obstetricians and Gynecologists

Association of Professors of Gynecology and Obstetrics

Society of Gynecologic Surgeons (elected 2000)

American Association of Gynecologic Laparoscopists

American Urogynecologic Society

International Continence Society

American Urologic Society

Bayard Carter Society

BuncombeCountyMedical Society

PUBLICATIONS:

Howland JL, Osrin D, Donatelli M, Theofrastous JP. Inhibition of erythrocyte membrane NADH dehydrogenase by nucleotides and uncouplers. Biochimica et Biophysica Acta 778(3):400-404, 1984.

Howland JL, Daugherty JW, Donatelli M, Theofrastous JP. Inhibition of the erythrocyte calcium-sensitive potassium channel by probucol. Pharmacology Research Communication 16(11):1057-1064, 1984

Theofrastous JP. Pelvic organ prolapse: Relationship to pelvic floor dysfunction. Postgraduate Obstetrics & Gynecology 1994;14/15

Bump RC, Elser DM, Theofrastous JP, McClish DK. Valsalva leak point pressures in women with genuine stress incontinence: Reproducibility, effect of catheter caliber, and correlations with other measures of urethral resistance. Am J Obstet Gyencol 1995;173:551-7

 

Theofrastous JP, Bump RC. Periurethral collagen injections for the treatment of urinary incontinence due to intrinsic urethral sphincteric deficiency. Postgraduate Obstetrics & Gynecology 1995;15(3):1-7

Theofrastous JP, Bump RC, Elser DM, Wyman JF, McClish DK. Correlation of Valsalva leak point pressures and urethral pressure profilometry variables with measures of incontinence severity in women with pure genuine stress incontinence. Am J Obstet Gynecol; 1995;173:407-14

 

Theofrastous JP, Cundiff GW, Haris RL, Bump RC. The Effect of Vesical Volume on Valsalva Leak Point Pressures in Women with Genuine Stress Urinary Incontinence. Neurourol Urodynam 1995;14:409-10

 

Bump RC, Hurt WG, Elser DM, Theofrastous JP, Fantl JA, McClish DK.  Cough pressure transmission ratios predict lower urinary tract function in women soon after surgery for genuine stress incontinence or severe pelvic organ prolapse. Neurourol Urodynam 1995;14:431-2

Bump RC, Hurt WG, Elser DM, Theofrastous JP, Fantl JA, McClish DK. Reliability of Intra-operative anatomic, endoscopic, and urodynamic measurements and their correlation with post-operative pressure transmissions in women undergoing bladder neck suspension surgery. Neurourol Urodynam 1995;14:490-1

Theofrastous JP, Cundiff GW, Harris RL, Bump RC. The effect of vesical volume on Valsalva leak point pressures in women with genuine stress urinary incontinence. Obstet Gynecol 1996;87:711-14

Hall AF, Theofrastous JP, Cundiff GW, Harris RL, HamiltonL, Swift S, Bump RC. Inter- and intra-observer reliability of the proposed ICS/SGS/AUGS pelvic organ prolapse classification system.  Am J Obstet Gynecol  1996:175:1467-71. (Second Prize Presidential Resident/Fellow Paper, presented3/6/96 Society of Gynecologic Surgeons 22nd Scientific Meeting,Albuquerque,New Mexico).

Bump RC, Hurt WG, Theofrastous JP, Addison WA, Fantl JA, Wyman JF, McClish DK, and the Continence Program for Women.  Randomized prospective comparison of needle colposuspension versus endopelvic fascia plication for potential stress incontinence prophylaxis in women undergoing vaginal reconstruction for stage III or IV pelvic organ prolapse.  Am J Obstet Gynecol 1996;175:326-35

Fantl JA, Newman DK, Colling J, et al. Managing Acute and Chronic Unrinary Incontinence. Clinical Practice Guideline. No. 2 1996 Update.Rockville,MD:U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research. AHCPR Pub. No. 96-0686. March 1996. Statisitical consultant.

Theofrastous, MD, AddisonWA, Timmons MC. Voiding function in postmenopausal women following surgery for pelvic organ prolapse. J Reprod Med 1996;12:881-4

Harris RL, Cundiff GW, Theofrastous JP, Bump RC.  Bladder compliance in neurologically intact women.  Neurourol Urodynam 1996;15:483-8

Harris RL, Cundiff GW, Theofrastous JP, Bump RC.  Pressure transmission ratio reproducibility in stress continent and stress incontinent women.  Neurourol Urodynam 1997;16:161-66

Theofrastous JP, Wyman JF, Bump RC, McClish DK, Elser DM, Robinson D, Fantl JA, and the Continence Program for Women Research Group. The relationship between urethral and vaginal pressures during pelvic muscle contraction.  Neurourol Urodynam 1997;16:553-8.

Evins GG, Theofrastous JP. Postpartum depression: a review of postpartum screening.  Primary Care Update for OB/GYNs 1997;4:241-6

Cundiff GW, Harris RL, Theofrastous JP, Bump RC. Pressure transmission ratio reproducibility in stress continent and stress incontinent women. Neurourol Urodyn 1997;16(3):161-166

Theofrastous JP, Swift SE. The clinical evaluation of pelvic floor dysfunction. Obstet  Gynecol ClinN America1998:25:783-804

Bump RC, Hurt WG, Elser DM, Theofrastous JP, AddisonWA, Fantl JA, McClish DK. Understanding lower urinary tract function in women soon after bladder neck surgery. Neurourol Urodyn 1999;18(6):629-37

Theofrastous JP, “The Neurophysiology of Pelvic Floor Dysfunction” in Lentz GM, editor Urogynecology (Arnold, London 2000) pp 64-84

Evins GG, Theofrastous JP. Galvin SL. Postpartum depression: a comparison of screening and routine clinical evaluation.  Am J Obstet Gynecol 2000;182:

Theofrastous JP, Wyman JF, Bump RC, McClish DK, Elser DM, Bland DR, Fantl JA, and the Continence Program for Women Research Group. Effects of pelvic floor muscle training on strength and predictors of response in the treatment of urinary incontinence. Neurourol Urodyn  2002;21(5):486-90

Theofrastous JP, Cobb DL, VanDyke AH. A Randomized trial of suprapubic versus transurethral bladder drainage after open Burch retropubic urethropexy. J Pelvic Surgery 2002;8:72-7

Theofrastous JP, Simpkins K. Urinary retention and intravesical hemorrhage following urethral collagen injections in women using warfarin. Int Urogynecol J Pelvic Floor Dysfunct 2002;13:268-9.

Theofrastous JP, Swift JE. Urodynamic Testing in Bent AE, Ostergard DO, Cundiff GC, Swift SE editors Urogynecology 5th edition, (Lippincott Williams & Wilkins, Philadelphia 2003) pp 115-39

Swift JE, Theofrastous JP. “The Clinical Evaluation of Pelvic Organ Prolapse” in Staskin D, Cardozo L, editors Evaluation and Management of Urinary Incontinence and Prolapse (in press)

Harkness CB, Theofrastous JP, Ibrahim SN, Galvin SL, Lawrence HC. A Comparison of Papanicolaou and Thin-layerCervical Cytology with Colposcopic Biopsy Control. J Reprod Med 2003;48:681-6

Luck AM, Galvin SL, Theofrastous JP. Suture erosion & wound dehiscence with permanent versus absorbable suture in posterior vaginal surgery. J Pelvic Medicine & Surgery 2004;10:S14

Ross BE, Pirkle AH, Van Dyke AH,LawrenceHC, Galvin SL, Theofrastous JP. A randomized double-blinded study of the use of vasopressin at vaginal hysterectomy. J Pelvic Medicine & Surgery 2004;10:S26

McLennan MT, Theofrastous JP, Melick CF.  Randomized trial of cefazolin prophylaxis for open Burch retropubic urethropexy. J Pelvic Medicine & Surgery 2004;10:239-44

As a member of the Continence Program in Women Research Group:

Shumaker SA, Wyman JF, Uebersax JS, McClish D, Fantl JA for the Continence Program In Women Research Group. Health-related quality of life measures for women with urinary incontinence the Incontinence Impact Questionnaire and the Urogenital Distress Inventory. Quality of Life Res 1994;3:291-306

 

 Uebersax JS, Wyman JF, Shumaker SA, McClish DK, Fantl JA, and the Continence Program for Women Research Group. Short forms to assess life quality and symptom distress for urinary incontinence in women: the incontinence impact questionnaire and the urogential distress inventory. Neurourol Urodynam 1995;14:131-9

Wyman JF, Fantl JA, McClish DK, Bump RC and the Continence Program for Women Research Group.  Comparative efficacy of behavioral interventions in the management of female urinary incontinence.  J Am Med Assoc 1996, in review

Fantl JA, Bump RC, Robinson D, McClish DK, Wyman JF and The Continence Program for Women Research Group.  Efficacy of estrogen supplementation in the treatment of urinary incontinence. Obstet Gynecol 1996;88:745-49

Wyman JF, Fantl JA, McClish DK, Bump RC, and the Continence Program for Women Research Group. Comparative efficacy of behavioral interventions in the management of female urinary incontinence.  AM J Obstet Gynecol 1998;179:999-1007

Elser DM, Wyman JF, McClish DK, Robinson D, Fantl JA, Bump RC and the Continence Program for Women Research Group. The effect of bladder training, pelvic floor muscle training, or combination training on urodynamic parameters in women with urinary incontinence. Neurourol Urodyn 1999;18:427-36

Barber MD, Visco AG, Wyman JF, Fantl JA, Bump RC, RC and the Continence Program for Women Research Group. Sexual function in women with urinary incontinence and pelvic organ prolapse. Obstet Gynecol 2002;99:281-9

As a member of the Society of Gynecologic Surgeons Systematic Review Group . 

Clinical practice guidelines on vaginal graft use from the society of gynecologic surgeons. Obstet Gynecol. 2008;112:1123-30.

 Matteson KA, Abed H, Wheeler TL 2nd, Sung VW, Rahn DD, Schaffer JI, Balk EM; for the Society of Gynecologic Surgeons Systematic ReviewGroup. A Systematic Review Comparing Hysterectomy with Less-Invasive Treatments for Abnormal Uterine Bleeding. J Minim Invasive Gynecol. 2011 Nov 10.

SCIENTIFIC PRESENTATIONS

Correlation of Valsalva leak point pressures and urethral pressure profilometry variables with measures of incontinence severity in women with pure genuine stress incontinence. American Urogynecologic Society 1994 Annual Scientific Program,Toronto,Ontario

Correlation of Valsalva leak point pressures and urethral pressure profilometry variables with measures of incontinence severity in women with pure genuine stress incontinence.South AtlanticAssociation of Obstericians and Gynecologists 1995 Annual Meeting,Hot Springs,VA

The Effect of Vesical Volume on Valsalva Leak Point Pressures in Women with Genuine Stress Urinary Incontinence. American Urogynecologic Society 1995 Annual Scientific Session,Seattle,WA.

The Effect of Vesical Volume on Valsalva Leak Point Pressures in Women with Genuine Stress Urinary Incontinence. International Continence 1995 Annual Scientific Session, 1995,Sydney,Australia

Clinical Predictors of Pelvic Muscle Function. American Urogynecologic Society 1996 Annual Scientific Session,New Orleans,LA

The Relationship Between Pelvic Muscle Strength and Incontinence Severity Following the Behavioral Treatment of Urinary Incontinence. American Urogynecologic Society 1997 Annual Scientific Session,Tuscon,AZ

A Randomized Trial of Suprapubic versus Transurethral Bladder Drainage Following Burch Retropubic Urethropexy. Society of Gynecologic Surgeons Annual Scientific Session 2000,New Orleans,LA

Urinary Retention Following Periurethral Collagen Injections in Women Using Anticoagulation. James P Theofrastous, MD, Kenny Simpkins, MD. American Urogynecologic Society 2000 Annual Scientific Meeting, Hilton Head, SC

A randomized double-blinded study of the use of vasopressin at vaginal hysterectomy. American Urogynecologic Society/Society of Gynecologic Surgeons 2004 Annual Scientific Session,San Diego, CA

McLennan MT, Theofrastous JP, Melick CF.  Randomized trial of cefazolin prophylaxis for open Burch retropubic urethropexy. J Pelvic Medicine & Surgery 2004;10:239-44

Luck AM, Galvin SL, Theofrastous JP. Suture erosion & wound dehiscence with permanent versus absorbable suture in reconstructive posterior vaginal surgery. Am J Obstet Gynecol 2005;192:1626-9

Funded Research:

1993-1995 Coinvestigator:  Continence Program for Women- Randomized double-blinded study of the effects of estrogen replacement on genuine stress urinary incontinence.

1993- 1995 Coinvestigator:  Continence Program for Women- Randomized  surgical study of the effects of concomitant urethropexy in women undergoing surgical correction of severe genital prolapse.

[Both studies supported by Grant UO1AG05170-06 from

the national Institute on Aging 1989-94]

1995 Principal Investigator:  Surgical treatment of genuine stress incontinence due to intrinsic sphincteric deficiency: A stratified randomized prospective comparison of Burch colposuspension, pubovaginal sling, and periurethral collagen injections. (Awarded the 1995 ACOG/Ethicon Award for Innovations in Gynecologic Surgery)

July 2000-2002 Principal Investigator: Pelvic Muscle Exercises Following Parturition: A Randomized Prospective Trial with Neurophysiologic and Kinesiologic Evaluation.AmericanCollegeof Obstetricians & Gynecologists District IV  Special Projects Award